Close relationships between in vitro ADMET and DMPK research in pre-clinical drug discovery

One year in circulation – an exciting journey for ADMET & DMPK

It is now almost a year since ADMET & DMPK launched. The current issue will be the final one for 2013. We are happy to report that it has been a very exciting year for the journal. In particular, we have published a range of articles, such as book reviews, original scientific papers, perspectives, opinions and mini reviews covering different areas of interest to the journal. This reflects the d...

Toward in silico structure-based ADMET prediction in drug discovery.

Quantitative structure-activity relationship (QSAR) methods and related approaches have been used to investigate the molecular features that influence the absorption, distribution, metabolism, excretion and toxicity (ADMET) of drugs. As the three-dimensional structures of several major ADMET proteins become available, structure-based (docking-scoring) computations can be carried out to compleme...

the investigation of research articles in applied linguistics: convergence and divergence in iranian elt context

چکیده ندارد.

: metadiscourse in introduction sections of applied linguistics and physics research articles: exploring variation in frequency and type

abstract in written mode of language, metadiscourse markers are used commonly to help writers in general and academic writers in particular to produce coherent and professional texts. the purpose of the present study was to compare introduction sections of applied linguistics and physics articles regarding their use of interactive and interactional metadiscourse markers based on the model pro...

De-Risking Drug Discovery Programmes Early with ADMET